加拿大Silicycle硅胶填料SiliaMetS DEAM (R54430B)

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SiliaMetS DEAM (R54430B)

SiliaMetS DEAM (R54430B)

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Product Number Quantity  
R54430B-10G 10 g

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R54430B-25G 25 g

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R54430B-50G 50 g

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R54430B-100G 100 g

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R54430B-250G 250 g

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R54430B-500G 500 g

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R54430B-1KG 1 kg

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Details

SiliaMetS DEAM:  Your last step toward uncompromised purity
Effectively eliminates trace metals and boronic acids from products

SiliaMetS DEAM is a versatile scavenger designed to remove trace metal or boronic acids from reaction intermediates or final APIs. 

Metals Removed

  • Best scavenger for: Ag, Fe, Sn, Ti & Zn.
  • Good scavenger for: Se.

Scavengers are our class of functionalized silica that exhibit ability to bond (that is, to “scavenge”) various metal compounds or organic molecules dissolve in solution. In organic chemistry, formation of new bonds is of utmost importance and for this to be achieved, cross-coupling reactions are among the most important processes.
Initially these reactions used simple Pd-catalysts. However, the need to carry out more challenging coupling reactions has resulted in the development of more advanced catalysts and the use of many different metals.

Our SiliaMetS DEAM is your best choice for the scavenging of Titanium (Ti), and is also very powerful for Zinc (Zn), Iron (Fe) and Silver (Ag). Apart from the pharmaceutical industry, metal scavengers such as DEAM can be used in many other industries that need to recover low levels of precious metals, such as mining, refining, manufacturing, etc.

SiliaMetS DEAM is a very versatile scavenger, as it is dual-purpose:  it also is a highly effective tool to remove excess boronic acids from non-aqueous solutions. Boronic acids are widely used in organic synthesis and for a vast range of biological, medicinal and synthetic applications, particularly Suzuki coupling reactions.

Our SiliaMetS DEAM is the first DEAM-silica supported on the market, and is produced in large scale in our state-of-the-art facilities.

 

Scheme 1. Scavenging of a boronic acid using Si-DEAM

SiliaMetS DEAM (R54430B)

Table 1

Scavenging activity for metals by SiliaMetS DEAM
Complex Metal Solvent Scavenging Efficiency
Pd(OAc)2 Pd DMF 74 %
Zn(OAc)2 Zn DMF 96 %
FeCl3.6H2O Fe DMF 96 %
Ti(OiPr)4 Ti DMF 92 %
AgNO3 Ag DMF 88 %

Table 2

Scavenging activity for phenyl boronic acid by SiliaMetS DEAM for 1h at room temperature
Nb of eq. Scavenging Efficiency
1
2

Table 3

Typical Reaction Applications for SiliaMetS DEAM in order to remove catalyst
Reaction Catalyst to be scavenged
Suzuki coupling boronic acid
Lewis Acids TiCl4 & alkoxide derivatives
Sakuraï reaction TiCl4
Mukayama-Aldol reation
Knoevenagel condensation
Reductive alkylation of 1st to 2nd amines TIPP
Reductive amination of enolizable carbonyls

Documentations

SPECIFICATION SHEET

Download the Specification Sheet

APPLICATION NOTE

Application Note for SiliaMetS DEAM

Additional Information

Particle Shape Irregular
Array DEAM
Family / Formats SiliaMetS® (Metal Scavengers)
Particle Size 40 – 63 µm / 230 – 400 mesh
Pore Size 60 Å
Endcapping Endcapped
Storage Condition Keep dry under Argon
Solvent Compatibility All organic solvents
Typical Density 679 g/L
Molecular Loading 0.85 mmol/g
Color Off-white